·From: North Follow Interstate 45 or Interstate 59 South. From Interstate 45 connect or Interstate 59 South. From Interstate 45 connect to Interstate 59 South near downtown Houston. Follow Interstate 59 to Highway 288 South. Exit 288 South at McGregor Street. Take a right on McGregor and follow it to Main Street. Take a left on Main. Follow Main one mile to the Best Western Plaza Hotel and Suites Medical Center will be on the right. ·From: South Follow Interstate 45 North to the south loop of Interstate 610. Go west on the south loop of Interstate 610. Follow Interstate 610 to Main street exit. Go right on Main Street. Follow Main Street two miles until you pass Holcombe. The Best Western Plaza Hotel and Suites at Medical Center will be on the left side just past Holcombe. ·From: East Follow Interstate 10 to the east loop of Interstate 610. Take Interstate 610 South. Follow Interstate 610 South until you have to go west. Follow Interstate 610 West to the Main Street exit. Exit Main and turn right on Main. Follow Main two miles until you pass Holcombe. The Best Western Plaza Hotel and Suites Medical Center will be on the left side of Main after you pass Holcombe. ·From: West Follow Interstate 10 to the west loop of Interstate 610. Go south on Interstate 610. Follow Interstate 610 South to the Bellaire exit. Exit on Bellaire and take a left. Bellaire turns into Holcombe. Follow Holcombe to Main and take a left. The Best Western Plaza Hotel and Suites Medical Center will be on the left hand side of Main. ·From: George Bush Airport (IAH) Follow the signs toward Interstate 59. Take Interstate 59 South. Follow Interstate 59 South to Highway 288 South. Exit 288 South at Holcombe Boulevard. Take a right on Holcombe and follow it to Main Street. Take a right on Main. The Best Western Plaza Hotel and Suites Medical Center will be on the Left. ·From: Hobby Airport (HOU) Follow the signs toward Interstate 45. Take Interstate 45 North. Follow Interstate 45 North to the south loop of Interstate 610. Take Interstate 610 WEST. Follow Interstate 610 to Main Street exit. Go right on Main Street. Follow Main Street two miles until you pass Holcombe. The Best Western Plaza Hotel and Suites at Medical Center will be on the left side just past Holcombe.