·From: The north. Follow Interstate 75 north to Knoxville, take Interstate 40 east to Exit 407 turn right onto Highway 66. follow Highway 66 it will turn into US 441 South in Sevierville. Follow US 441 into Gatlinburg, the Best Western Twin Islands is between traffic lights 3 and 5 on the right. ·From: The south. Follow Interstate 75 south to Knoxville, take Interstate 40 east to Exit 407 turn right onto Highway 66. follow Highway 66 it will turn into US 441 South in Sevierville. Follow US 441 into Gatlinburg, the Best Western Twin Islands is between traffic lights 3 and 5 on the right. ·From: The east. Take Interstate 40 east to Exit 407 turn right onto Highway 66. follow Highway 66 it will turn into US 441 South in Sevierville. Follow US 441 into Gatlinburg, the Best Western Twin Islands is between traffic lights 3 and 5 on the right. ·From: The west. Take Interstate 40 east to US 321 South Exit 440 toward Gatlinburg. Merge onto TN- 73/Denton Road. Turn right onto Wilton Springs Road/TN-73/Major Charles L McGaha Highway. Continue to follow Wilton Springs Road 2¼ miles. Turn left onto US 321/TN-32/TN-73 6½ miles then turn right onto 321/TN-73 18 miles into Gatlinburg. Turn left onto US 441 Parkway the Best Western Twin Islands is approximately ½ block on the right.